BrachyClip Technology
The only solution specifically designed for open, minimally invasive laparoscopic, and robotic procedures
What is BrachyClip®?
A novel device for precise radiation delivery during minimally invasive surgery
Ergonomic Handheld Device
- •Precision and ease of use in minimally invasive surgeries
- •Compatible with standard laparoscopic and robotic trocars
- •Seamless integration into existing workflows
- •Holds magazine of up to 20 clips for continuous deployment
- •Tactile feedback ensuring secure placement
Titanium Clip Technology
- •Encapsulates radioactive seeds for stable positioning
- •Ensures immobile, precise radiation dose distribution
- •Uses standard available seeds incorporated into delivery system
- •Radioactive seed inserted and sealed into titanium tube
Three Core Attributes
“Clip-like” applicators precisely secured in position and located directly adjacent to the surgical resection
Assuring a stable, clinically efficacious, and accurate radiation distribution dose
Custom made implants that adapt specifically to the tumor's anatomy; applicable to any site in the body
Key Requirements for Minimally Invasive IPSB
"Prior techniques have been related to poor apposition of radioactive seeds. BrachyClip assures persistent placement and appropriate delivery of planned radiation."
Accurate seed placement
via any surgical approach
Secure fixation to ensure
efficacious dose distribution
Ability to precisely conform
IBSP to the residual margin
Minimal or no personnel
risk of radiation exposure
Developed by IPSB Experts
BrachyClip was engineered by leading radiation oncologists and medical physicists who pioneered IPSB techniques, specifically designed to overcome existing limitations
What Makes BrachyClip Different
Minimally Invasive
Secure positioning of radioactive seeds with minimal tissue disruption through a handheld applicator system
Precise Dosimetry
Advanced dosimetry planning ensures optimal radiation delivery while protecting healthy tissue
Immediate Treatment
Intra-operative application eliminates the need for repeat surgeries or external beam radiation courses
Platform Technology
Designed for multiple tumor types and future payload delivery capabilities beyond brachytherapy seeds
The BrachyClip Technology
A comprehensive solution for minimally invasive intra-operative permanent seed brachytherapy
ACCURATE
Precisely targeted radiation delivery to high-risk surgical margins
Optimized Dosimetry
Advanced planning ensures optimal dose distribution to tumor bed while minimizing exposure to healthy tissue
Predictable Outcomes
Consistent seed placement enables reproducible dosimetry calculations and treatment planning
Real-Time Verification
Radiopaque titanium markers allow for immediate imaging confirmation of placement
Clinical Impact
Accurate radiation delivery reduces the need for additional interventions and improves patient outcomes through targeted treatment of at-risk tissue.
Monte Carlo Dosimetry Analysis
Advanced computational modeling validates BrachyClip's precise and uniform radiation dose distribution
Single Seed Dose Distribution
Relative dose distribution from a single BrachyClip seed showing concentrated, predictable radiation delivery
20-Seed Array Dose Distribution
Combined dose distribution from a 20-seed BrachyClip array demonstrating uniform coverage of the target area
Dose Uniformity — Above Clip (Y=+1cm)
Absorbed dose 1cm directly above the seed: 0.203 Rad/hr/mCi — demonstrating highly uniform dose delivery
Dose Uniformity — Below Clip (Y=-1cm)
Absorbed dose 1cm directly below the seed: 0.158 Rad/hr/mCi — confirming symmetric radiation penetration
Intra-Operative Permanent Seed Brachytherapy
Proven Clinical Benefits
Most frequently employed when surgical margins are close or positive
Highly effective and minimally toxic "boost" dose of irradiation maximizes local tumor control
Over 80 years of clinical efficacy and safety data
The Clinical Challenge
IPSB, though highly effective, is underutilized because current techniques are not adaptable to minimally invasive surgical procedures.
Annual U.S. cases with close/positive margins
Positive surgical resection and close (<2mm)
Local tumor recurrence cases annually
"Local tumor recurrence has a profound impact on the ability to cure cancer. It requires multidisciplinary management that is expensive and rarely successful. The best strategy to manage local tumor recurrence is to do everything possible to avoid it."
Dr. Douglas Arthur
Professor and Chairman, Department of Radiation Oncology
Massey Cancer Center, Virginia Commonwealth University
Endorsed by Leading Clinicians
Key opinion leaders recognize BrachyClip's potential to transform surgical margin management
“This is a very nice solution to a longstanding problem.”
Dr. Gyan Pareek
Chief of Urology, Miriam Hospital, The Warren Alpert Medical School of Brown University
“This is a very clever idea that should work very well!”
Dr. Scott Kelley
Surgical Oncologist, Watson Clinic; Chief of General Surgery, Lakeland Regional Medical Center
Projected Clinical Impact
Projected annual healthcare savings from reduced re-excisions and complications
Local control rates through precise radiation delivery to high-risk margins
Patient burden with single-procedure treatment vs. repeat surgeries
Comparison to Alternative Treatments
BrachyClip offers significant advantages over external beam radiation therapy (IMRT, SBRT) and systemic treatments:
- ✓Single intra-operative treatment vs. weeks of daily radiation
- ✓Localized radiation minimizes systemic side effects
- ✓Lower total cost than extended radiation courses
- ✓Improved quality of life with reduced treatment burden
What Experts Are Saying
With the rise of minimally invasive, robotic surgical techniques, IPSB became impractical and forgotten. BrachyClip gives us back a powerful tool to minimize the risk of local tumor recurrence.
Dr. Gyan Pareek
Chief of Urology, Lifespan Hospitals
The Warren Alpert Medical School at Brown University
President, Brown Urology
With BrachyClip, the potential benefit is so large and the risk of complications so low that I am tempted to use them on every patient.
Dr. Scott Kelley
Surgical Oncologist at Watson Clinic
Chief of General Surgery at Lakeland Regional Medical Center
Prior techniques have been related to poor apposition of radioactive seeds. BrachyClip assures persistent placement and appropriate delivery of planned radiation.
Dr. Philip M. Devlin
Professor of Radiation Oncology
Harvard Medical School
BrachyClip Will Improve Outcomes
- ✓Projected to reduce local tumor recurrence by approximately one-third
- ✓Potential healthcare savings of ≅ $2 Billion per year
- ✓Adequate reimbursement codes already in place